Active Ingredients

• Irbesartan 150 mg
• Hydrochlorothiazide 12.5 mg

Dosage Form:

Film-Coated Tablets

Therapeutic Class

• Dual-Action Antihypertensive Combination (ARBs + Thiazide Diuretic)

Dosage

• Standard Adult Dose: One tablet once daily, taken with or without food.
• Dose Titration: If blood pressure remains uncontrolled after 2 to 4 weeks of treatment, the dosage may be adjusted according to clinical response as directed by the prescribing physician.
• Administration: Tablets should be swallowed whole with a glass of water, preferably at the same time each day (morning administration is recommended due to the mild diuretic effect).

Indications

1. Management of Essential Hypertension
2. Combination Therapy: Second-line therapy for patients requiring dual-action blood pressure reduction to reach target clinical guidelines.

Key Benefits

• Synergistic Dual-Action Control: Combines an Angiotensin II Receptor Blocker (Irbesartan 150 mg) with a Thiazide Diuretic (Hydrochlorothiazide 12.5 mg) to deliver additive and complementary blood pressure-lowering effects.
• Enhanced Efficacy over Monotherapy: Provides superior systolic and diastolic blood pressure reduction compared to either component used alone, helping more patients achieve target BP goals.
• 24-Hour Continuous Protection: Ensures smooth, sustained 24-hour blood pressure control with a single daily dose, minimizing morning blood pressure surges and cardiovascular risk.
• Optimized Tolerability Profile: Combining Irbesartan with Hydrochlorothiazide helps mitigate certain diuretic-induced metabolic side effects (such as hypokalemia), offering a balanced safety and tolerability profile.
• Improved Patient Compliance: Single-pill combination therapy simplifies the daily medication regimen, significantly enhancing long-term treatment adherence in hypertensive patients.